Wednesday, May 8, 2013

New cause for common lung problem

May 6, 2013 ? New research has found that in cases of lung edema, or fluid in the lungs, not only do the lungs fail to keep water out as previously believed, but they are also allowing water to pump in.

"Usually, our lungs pump fluid out of the air space, and it was previously believed that this pump mechanism just stopped when people had lung edema," said Dr. Wolfgang Kuebler, a scientist at St. Michael's Hospital. "But we've found not only do they stop pumping fluid out as they're supposed to do, they've gotten confused and are actually pumping in the reverse direction, bringing fluid into the lungs."

The research was published online in Proceedings of the National Academy of Sciences.

Dr. Kuebler said this finding has important implications for the treatment of lung edema, a common symptom of heart disease. Stopping the pumping mechanism, although seemingly counterintuitive, is protective for the lung and important for effective treatment.

For the first time, this explains why Lasix, a commonly prescribed drug, works in treating lung edema -- it simply prevents the pumps from allowing fluid into the air spaces. Lasix was previously believed to work exclusively by targeting the kidneys.

"With this information, more effective drugs that target just the lungs, and not the kidneys, can now be developed," said Dr. Kuebler, also a scientist at the Li Ka Shing Knowledge Institute.

Dr. Kuebler points out that this mechanism of pumping fluid into the air spaces is similar to what happens in the fetal lung. In the womb, the lung works to pump fluids in and only after the baby is born, does that pumping mechanism reverse itself to pump fluid out. "You can actually now interpret lung edema as a regression of the adult lung to a fetal stage," he said.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/6FRd0pFk184/130506132444.htm

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Friday, May 3, 2013

Grim OECD forecasts on Italy underline task for new PM Letta

By Gavin Jones

ROME (Reuters) - Italy's economy will contract by more than expected this year and its public finances will deteriorate in 2013 and 2014, the Organisation for Economic Cooperation and Development said on Thursday.

The OECD's 122 page Economic Survey of Italy, which said Rome's fiscal deficit will exceed European Union limits this year and next, underlined the tough challenges faced by Enrico Letta's new government which took office last week.

The euro zone's third largest economy will shrink by 1.5 percent in 2013, compared with a forecast of a 1.0 percent fall in output made in November, the Paris-based institute said. It projected anemic growth of 0.5 percent in 2014.

"Fiscal consolidation, declining investment and the rebuilding of household savings, along with tight credit conditions, are likely to hold back growth in coming months," the report said.

All the OECD's main economic and public finance forecasts were more negative than the official targets that Letta has inherited from former Prime Minister Mario Monti.

Despite waves of austerity adopted by Monti's government, Italy's huge public debt will rise to a new record of 131.5 percent of output this year, the OECD said.

In 2014 debt will climb further to 134.2 percent, rather than fall to 129 percent as envisaged by Rome's targets.

Italy has the euro zone's second-largest debt after Greece as a percentage of gross domestic product. When Monti took office in 2011, the debt stood at 120.8 percent of GDP.

Italy must reverse this upward debt trend, the OECD said, "either with a balanced budget or small fiscal surplus, supported by strong implementation of growth-enhancing structural reforms."

However, Italy's progress towards a balanced budget has also come to a halt, according to the OECD's forecasts.

It said the budget deficit will rise to 3.3 percent of output this year, above the EU's 3 percent limit and compared with Rome's 2.9 percent target.

The deficit would reach 3.8 percent in 2014, more than twice the official target of 1.8 percent, the OECD projected.

Several members of Letta's left-right coalition government have urged him to try to re-negotiate Italy's public finance commitments with the European Union, saying the country needs to cut taxes and spend more to stimulate the economy.

The OECD urged Italy to consolidate its finances through spending curbs rather than higher taxes and to strengthen previous efforts by Monti to tackle corruption.

It said Italy needed to better align wages with productivity to help restore competitiveness, and called for further reform of the labor market, welfare and the justice system.

(Reporting by Gavin Jones; editing by James Mackenzie)

Source: http://news.yahoo.com/grim-oecd-forecasts-italy-underline-task-pm-letta-073510117.html

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An Earthy, Nature-Flanked Home in Sonoma ... - AOL Real Estate


winning Sonoma County home

We thought this week's #housepornthurs competition was a no-brainer, but we were pleasantly surprised: The majority of you voted for an earthy, nature-flanked home in California's Sonoma County over a swanky $16.5 million New York City townhouse!

A handsome choice, we think. The gorgeously peaceful, earth-tone home is nestled among 1.6 sprawling acres of beautiful gardens and towering trees. The two-bedroom house (holding its own at $1.8 million) boasts a large gallery with nature views, a "warm and inviting" library, a large gourmet kitchen and a guest cottage. The home, though spacious at over 2,000 square feet, has a charmingly cozy feel about it. Nice choice, y'all.

See the listing for more details.

Find more homes for sale in Sonoma County, Calif., or search listings in your area.

The #housepornthurs contest is a weekly Twitter conversation hosted by @aolrealestate. Tweet listings every Thursday to AOL Real Estate with the hashtag #housepornthurs for a chance to have one of your submissions featured as a House of the Day the following week.


See more Houses of the Day on AOL Real Estate.

Got a tip for House of the Day? Know of an exceptional or unusual property currently listed for sale? Please email colin.croughan@teamaol.com with your suggestions and be sure to include links to listing details and photos. (Due to the volume of response, we unfortunately are unable to reply to each submission.)

More on AOL Real Estate:
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Follow us on Twitter at @AOLRealEstate or connect with AOL Real Estate on Facebook.

Source: http://realestate.aol.com/blog/on/sonoma-county-home-for-sale/

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Why No One?s Winning in Washington

Each party emerged from the 2012 presidential election facing one overriding political test. So far, both are flunking.

For Republicans, the key question was whether a congressional caucus rooted in the nation?s most conservative areas could court the broader coalition the party needs to regain the presidency. For President Obama and his fellow Democrats, the issue was whether they could deliver better economic results?or at least formulate an agenda for growth that persuasively contrasted with the GOP?s. Nearly six months after the election, neither side can claim much progress.

The Republican Party, which has lost the popular vote in five of the past six presidential elections, has an unmistakable need to broaden its national reach. In 2012, Mitt Romney captured only 206 Electoral College votes while winning a larger share of white voters than Ronald Reagan did in his 1980 landslide. And each of the key groups in Obama?s ?coalition of the ascendant??minorities, the millennial generation (ages 18-31), and college-educated white women?will likely make up a larger share of voters in 2016 than in 2012. In presidential elections, the possession arrow points toward Democrats: Until Republicans cut into the coalition of the ascendant they are unlikely to win the White House.

The GOP?s conundrum is that because most of its House or Senate members represent reliably conservative, and often preponderantly white, constituencies, few have a direct incentive to court those voters. Focused on their local politics, they are solidifying their party?s identification with policies that alienate the Democrats? national coalition.

These forces were highlighted in the recent Senate vote blocking expanding background checks for gun purchases. Those checks have drawn overwhelming public support in opinion polls before and after the vote, and are especially popular with minorities and college-plus white women. Yet only four Senate Republicans supported them. Every GOP senator from a swing state that Obama and Romney seriously contested voted no.

Some analysts have argued that few voters will punish Republicans directly for that opposition. But rather than parsing each issue, many voters aggregate a candidate?s views to reach a cumulative judgment about whether he or she shares their basic values. That dynamic is especially powerful in the presidential election.

The GOP?s near-lockstep rejection of expanded background checks on gun sales will provide Democrats another brick in a wall that includes widespread Republican opposition to gay marriage, abortion, no-cost contraception in health insurance, and funding for Planned Parenthood. All of these positions stamp the GOP as primarily representing the cultural values of rural, heavily evangelical, and largely white heartland states?and not the prevailing beliefs of more diverse, cosmopolitan, and suburban states. Republicans must flip some of the latter to win the White House. Compounding the risk, the gun vote suggests that Republicans from conservative constituencies see little need to concede to overall public opinion on issues opposed by their party?s base. If they apply that logic to the impending immigration debate, the reform that GOP strategists consider indispensable to attracting more minorities in 2016 could face crippling resistance. The risk is greatest in the House, where nearly four-fifths of Republicans represent districts in which whites exceed their national share of the voting-age population.

The GOP?s struggle to culturally connect with the coalition of the ascendant will help Democrats sustain it. But the president?s inability to deliver better economic outcomes presents a powerful counterforce. The latest Allstate/NationalJournal Heartland Monitor Poll, released last week, offered a keening wail of economic anxiety and discontent. About three-fifths of those polled said they feared falling into a lower economic class, and fewer than one-fourth considered it ?very realistic? that they could meet such basic financial goals as saving for retirement or their children?s college education. Among whites, only 21 percent?tied for the lowest share ever?said Obama?s agenda was increasing opportunity for people like them.

By solid margins, the key groups in Obama?s coalition still said they preferred him to the GOP on economic issues. But college-educated white women expressed dim opinions of his economic performance (only 28 percent thought his agenda would increase their opportunities), and minorities and millennials were much more likely than others to describe their economic situation as poor or only fair. Last fall, Obama won the support of just over seven in 10 Hispanics, but roughly as many in the new poll described their economic standing in those grim terms.

Although the confrontations over guns and immigration that Obama has pressed create cultural hurdles for the GOP, they may also prompt voters to conclude, as they did in his first two years, that he is focusing on priorities other than their economic concerns. And even when Obama has addressed the economy, the continuing stalemate over deficit reduction has overshadowed his proposals to promote growth through public investments?which are, in any case, relatively modest. If growth remains lackluster, Democrats in 2014 and 2016 could still run effectively on cultural affinity and against a GOP economic alternative likely centered on tax and spending cuts. But Democrats can never be entirely secure about their hold on voters who see neither economic gains nor a clear plan to deliver them.

Source: http://news.yahoo.com/why-no-one-winning-washington-232741751.html

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Thursday, May 2, 2013

The Bank of Japan's bold new board

TOKYO (Reuters) - The Bank of Japan unleashed the world's most intense burst of monetary stimulus on April 4, promising to inject about $1.4 trillion into the economy in less than two years.

Here are short profiles of the Bank of Japan's board that took the decision:

HARUHIKO KURODA, 68, GOVERNOR - He was plucked from the Asian Development Bank by Prime Minister Shinzo Abe to deliver radical reflationary policies at the Bank of Japan. Took office in March. Kuroda had long criticized the BOJ for doing too little, too late to end deflation and boost the Japanese economy. A voracious reader of books ranging from philosophy to detective novels.

KIKUO IWATA, 70, DEPUTY GOVERNOR - He was among the most firmly established critics of the BOJ, arguing the central bank could have ended deflation sooner with more aggressive action. Took office in March. He had advocated the BOJ target base money - cash and deposits at the central bank - in guiding policy. That was one of the steps the BOJ took on April 4.

HIROSHI NAKASO, 59, DEPUTY GOVERNOR - He was in charge of the central bank's international affairs before being named to Kuroda's team in March. With his fluent English and deep overseas contacts, Nakaso played a key role in trying to contain the damage to global banks from the collapse of Lehman Brothers in 2008.

KOJI ISHIDA, 65 - The veteran banker voiced caution over shifting the BOJ's policy framework too quickly, even as governor-nominee Kuroda was advocating aggressive action. Ishida feared that overloading the bank's balance sheet with long-term debt could bind its hands on future decisions. He has been willing to cut interest rates, proposing in December cutting the 0.1 percent floor on money-market rates. His proposal was rejected 8-1.

TAKEHIRO SATO, 51 - The former economist at Morgan Stanley MUFG Securities had argued for buying foreign bonds as a future option for the BOJ. He backed down after the idea drew heat from other G7 nations that consider it tantamount to currency intervention. Initially regarded as a policy dove, the amateur violinist was one of two members who dissented to the BOJ's January decision to double its inflation target to 2 percent.

RYUZO MIYAO, 48 - A soft-spoken former academic known for his research on inflation-targeting, he is considered among the board's keenest proponents of unorthodox easing. Miyao has proposed several policy changes in the past, including boosting the BOJ's asset-buying and loan scheme, but without garnering a consensus.

YOSHIHISA MORIMOTO, 68 - The former utility executive has always voted with the majority since joining the board in 2010. He has also warned the government must play its role in beating deflation by pursuing structural reform and deregulations to make Japan an easier place to do business.

SAYURI SHIRAI, 50 - The former International Monetary Fund economist often sided with ex-governor Masaaki Shirakawa, who argued the BOJ had already offered enough stimulus. The board's only woman, while mostly voting with the majority, surprised markets in March by proposing, shortly before Kuroda joined, that the BOJ combine its two bond-buying schemes to make it easier to buy longer-dated debt - an idea the incoming governor was floating. The proposal was rejected 8-1 before being adopted at Kuroda's first meeting in April.

TAKAHIDE KIUCHI, 49 - The former Nomura Securities chief economist was one of the two board members voting against raising the BOJ's inflation target to 2 percent in January. He said this was far above a sustainable level for Japan, which has seldom had inflation that high, even during asset bubbles. Kiuchi, despite earlier warning against loading up on longer-dated debt, joined the rest of the board in voting for most of Kuroda's reflationary policies in April. But he proposed watering down the BOJ's commitment to hitting its inflation target in two years. His proposal was rejected 8-1.

(Reporting by Leika Kihara; Editing by Bill Tarrant)

Source: http://news.yahoo.com/bank-japans-bold-board-120333994.html

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Wednesday, May 1, 2013

ME Bank picks 'cheaper' Microsoft stack over Linux

Members Equity Bank has claimed that the long term cost of using Windows Server 2012 and SQL Server 2012 will be cheaper than a Linux alternative, which the company claims would cost AU$100,000 more.

The bank, which is one of Australia's smaller banks with 250,000 customers, does not have any bank branches. It is currently undertaking an AU$57 million technology transformation program.

In late 2012, ME Bank picked the Temenos T24 CRM and product lifecycle-management software platform for its core banking platform, switching from the Windows-SQL-based NTBS and Solaris-based Ultratracs, which the bank had in place for close to a decade. The Temenos software was platform agnostic, meaning that the bank could have gone with either Windows or Linux for its server operating systems.

ME Bank's enterprise architect Jem Richards said that after the bank examined the costs between the two platforms, including the cost of providing tech support, ultimately decided that the Windows Server 2012 and SQL Server 2012 option would be cheaper.

"Although the alternative Linux-based platform is essentially free to deploy, based on our past experience, we knew that it would cost more to support than Windows. This made the overall costs of the two operating systems approximately the same," he said in a statement.

"In addition, Microsoft and Windows community specialists were readily available to help us configure Temenos T24, whereas finding the relevant skills for the alternative platform with Temenos was proving to be a lot more difficult."

The company would not confirm which Linux platform it was considering deploying.

Richards said that the unnamed Linux platform would cost AU$100,000 more to upgrade, while the Microsoft licence would require no additional cost over five years.

"It was clear that if we deployed our core banking systems on Windows-SQL, the total cost of ownership would be substantially less than if we chose the alternative.?

Richards said that the decision would allow ME Bank to "consolidate internal IT skills on a single technology", and through the decommissioning of its legacy core banking system, it will save tens of thousands of dollars each year by requiring fewer external consultants to maintain the systems.

In March,?ME Bank announced that it has begun rolling out its virtual teller systems with a focus on contact centres, starting with Telstra's Melbourne contact centre.

Source: http://www.zdnet.com/au/me-bank-picks-cheaper-microsoft-stack-over-linux-7000014732/

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Bianca Jagger Style Evolution: The Woman Who Lives In White Suits (PHOTOS)

If you look up the definition of "style icon" in the dictionary, we think there should be a photo of Bianca Jagger next to the term... just sayin'. The Nicaragua-born beauty, who was once an actress and model, is now a prominent international human rights and climate change advocate. However, it wasn't Jagger's philanthropic efforts that brought her international fame, rather it was her 1971 nuptials to "Rolling Stones" frontman Mick Jagger. (Remember that white suit she sported for the wedding?) The marriage didn't last, but her impeccable sense of style has preserved.

Essays could be written about Jagger's work with the British Red Cross, Amnesty International and Human Rights Watch, but we want to call special attention to her fashion sense. (Who says you can't do good and look good?) Between her low-cut suits, oversized sunglasses and bowler hats, Jagger never wears a look that we don't covet.

In celebration of Bianca Jagger's 68th birthday on Thursday (May 2), we've rounded up some of her most memorable looks over the years. You might want to grab a pen and paper for this style evolution.

Want more? Be sure to check out HuffPost Style on Twitter, Facebook, Tumblr, Pinterest and Instagram at @HuffPostStyle.
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Do you have a style story idea or tip? Email us at stylesubmissions@huffingtonpost.com. (PR pitches sent to this address will be ignored.)

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Source: http://www.huffingtonpost.com/2013/05/01/bianca-jagger-style-photos_n_3188705.html

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