Friday, October 26, 2012

constitution warily: Heavy Equipment & Tools, Home Improvement ...

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Source: http://heavy-equipment-tools-home.blogspot.com/2012/10/grubbycup-garden-notes-path-of-garden.html

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Thursday, October 25, 2012

ObamaCare MIA (TIME)

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Health News - Protein regulation linked to intellectual disability

Genetics researchers at the University of Adelaide have solved a 40-year mystery for a family beset by a rare intellectual disability - and they've discovered something new about the causes of intellectual disability in the process.

While many intellectual disabilities are caused directly by a genetic mutation in the so-called "protein coding" part of our genes, the researchers found that in their case the answer laid outside the gene and in the regulation of proteins.

Protein regulation involves the switching on or off of a protein by specific genes. As a consequence in this case, either too much or too little of this protein can trigger the disability.

The team has studied a large (anonymous) Australian family of 100 people, who for generations have not known the source of their genetically inherited condition.

The disability - which results in a lower IQ, behavioural problems such as aggression, and memory loss, and is linked with developmental delays, epilepsy, schizophrenia and other problems - affects only the male family members and can be passed on by the female family members to their children.

Genetic samples taken from the family and laboratory testing involving mice have confirmed that the protein produced by the HCFC1 (host cell factor C1) gene is the cause of this disability.

"The causes of intellectual disability generally are highly variable and the genetic causes in particular are numerous. The vast majority of intellectual disabilities are due to genetic mutations in proteins, so it was rather unexpected that we found this particular disability to be due to a regulatory mutation," says the leader of the study, Professor Jozef Gecz from the University of Adelaide's School of Paediatrics and Reproductive Health.

"We've been researching this specific disability for 10 years and it's taken us the last three years to convince ourselves that the protein regulation is the key," he says.

"For the family, this means we now have a genetic test that will determine whether or not a female member of the family is a carrier, which brings various benefits for the family.

"From a scientific point of view, this widens our viewpoint on the causes of these disabilities and tells us where we should also look for answers for those families and individuals without answers.

"This is just the tip of the iceberg in understanding the impact of altered gene regulation on intellectual disability - the gene regulatory landscape is much bigger than the protein coding landscape. We have already found, and I would expect to continue finding, a number of other intellectual disabilities linked with protein regulation over the next 20 years or so."

Professor Gecz and his team have published their findings in this month's issue of the American Journal of Human Genetics.

Professor Jozef Gecz (email) School of Paediatrics & Reproductive Health The University of Adelaide Business: +61 8 8161 6339 Mobile: +61 429 170 699

Source: http://www.healthcanal.com/genetics-birth-defects/33293-Protein-regulation-linked-intellectual-disability.html

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When You're Almost Extinct, Your Price Goes Up

When a species gets rare, its market value rises. The higher its price, the more it's hunted. The more it's hunted, the rarer it gets. Not a happy cycle, and this keeps happening ...

Cycad Plant $50,000 Illustration by NPR

Cycads are stumpy, palm-like, very ancient plants, with a lineage that goes back 300 million years. Recently, they've become fashionable for high-end gardeners, and because they are so sought after, they're increasingly valuable. Poachers now snatch them from the wild, sometimes from private botanical gardens.

When Hurricane Frances swept through South Florida in 2004, thieves sneaked into Miami's mandatory evacuation area, slipped into the Fairchild Tropical Botanic Garden and stole over 30 endangered cycads. Some had been in the garden's collection for decades.

"These are unbelievably well-organized and highly profitable criminal syndicates," says Niel Maritz, who owns a game lodge in Limpopo, South Africa, with hundreds of cycads on it. He told The [Toronto] Globe and Mail, "They come in the full moon, they remove the plants at night," taking them away on trucks.

Some poachers even use helicopters, says Harvard's Piotr Naskrecki. In his new book, Relics, he describes how, for the rarest cycads, "small electronic identification chips have been installed deep in trunks. This, in theory, should help identify stolen plants when they are being transported across international borders. But it didn't take long for poachers to start using X-ray machines to locate and remove the chips."

Cycads in the wild are getting harder and harder to find.

Bluefin Tuna $736,000 Illustration by NPR

It was a single fish, caught off northeastern Japan and put on the auction block at Tokyo's Tsukiji fish market. It weighed 593 pounds. That's huge. And very rare. On Jan. 5, 2012, when the bidding ended, Kiyoshi Kimura, president of a sushi restaurant chain, had paid $1,238 per pound; that's $736,000 for one animal. Imagine being the fishing team who went to work that day and came home with three quarters of a million dollars.

Is any fish worth that much? Yes, says writer Trevor Corson (The Secret Life of Lobsters), but "it's money spent on advertising, not fish." Serving your customers a piece of one of the last great oceanic giants attracts media attention and gives the buyer bragging rights. People want to feast on something their neighbors, their friends can't have.

Tibetan Antelope Shawl $20,000 Illustration by NPR

It takes three chiru to make a shahtoosh. Chiru are delicate-looking antelopes that live in the high Tibetan plateaus. A shahtoosh, says the Times of India, is a "most prized" shawl, "beloved of Mughal emperors. It is very warm, yet so soft and fine" that you can bunch it up and slip it through the band of a wedding ring. It's also illegal, banned because three chiru have to be culled and skinned to make a single garment, and as shahtooshes became more popular, the chiru population in Tibet has plummeted.

Yet you can still buy a shahtoosh if you can afford the black market fee, which in India, says the Times, is as high as $20,000. "At these prices," the paper says, "the profitability of poaching overwhelms any official ban."

Governments still try to enforce the worldwide ban. A few years ago, U.S. federal marshals showed up in the Hamptons on Long Island and issued subpoenas to women who, they had reason to believe, had purchased a shahtoosh. Christie Brinkley was one of them (I read that she got it as a gift from Richard Gere). She and the others were asked to turn in their shahtooshes, which, for the most part, they did. The importers were charged, sentenced, but these "ultra soft, ultra thin, ultra warm" wraps, as Vanity Fair describes them, still attract customers in Europe and Asia, and prices are still rising.

Elephant Tusks $900/lb Illustration by NPR

This year, NPR's own Frank Langfitt went looking for illegal ivory in China and found it pretty much everywhere. Grace Gabriel, of the International Fund for Animal Welfare, says she's seen black market prices jump from $270 a pound to more than $900. A jump like that may not last, but since mature elephants carry about 22 pounds of ivory in their tusks, that works out to ? very roughly ? $19,800 an elephant.

The increase has had its effect. Elephant hunting has gotten more relentless, and more violent. In January 2012, according to National Geographic, "a hundred raiders on horseback charged out of Chad into Cameroon's Bouba Ndjidah National Park, slaughtering hundreds of elephants ? entire families ? in one of the worst concentrated killings since a global ivory trade ban was adopted in 1989. Carrying AK-47s and rocket-propelled grenades, they dispatched the elephants with ... military precision," and made off with more than a million dollars in ivory.

More recently, The New York Times reported how a team of wildlife rangers in Garamba National Park in the Congo came upon a group of poachers who, said chief ranger Paul Onyango, "opened up on us with PKMs, AKs, G-3s, and FNs." He said, "Most poachers are conservative with their ammo, but these guys were shooting like they were in Iraq. All of a sudden, we were outgunned and outnumbered." The rangers backed off.

Where does all this ivory go? Bryan Christy of National Geographic found buyers all over, most surprisingly among South Asian Catholics and Buddhist Temple shops, where religious icons are often made of illegal ivory. Do people know? Do they care? He ends his story with a 42-year-old Chinese entrepreneur who has just bought a couple of carved ivory "balls," one for himself, one for a friend. The entrepreneur plans to put his $50,000 ball in a conspicuous place in his new home where it will "hold the house against devils." This ivory trinket, says Christy, is "simply a very precious toy."

Christy then asks the entrepreneur, why did you buy this ivory thing? Why are they popular among young entrepreneurs?

"Value," he replies. "And art."
"Do you think about the elephant?" I ask.
"Not at all," he says.

And there's the problem. We aren't thinking when we choose a scarf, choose an exotic plant, buy an ivory ball. We should, but much too often, we don't.

Source: http://www.npr.org/blogs/krulwich/2012/10/24/163542173/when-you-re-almost-extinct-your-price-goes-up?ft=1&f=1007

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Wednesday, October 24, 2012

DEMI MOORE WINES AND DINES WITH NBA STAR

Does Demi Moore have a new love in her life? Maybe.

Page Six reports that the 49-year-old actress has been spending time in NYC with former Knick Baron Davis.

NBA star Davis, who is recovering from a knee injury and undergoing physical therapy in New York, was spotted dining with Moore and a group of friends at Meatpacking District hot spot Catch on Friday. Moore and Davis were also spotted at a late-night dinner with a few other friends last Wednesday at Ken & Cook in NoLIta.

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SoLoMo and Your Business ? Why You Should Care | Business 2 ...

Online marketing is changing.

Gone are the days when ?should I have a website?? was? a relevant question.? Now, simply having ?only? a website is not enough for a B2B business and even more so for B2C businesses and retailers.? Customers are web savvy and increasingly social and mobile savvy, which is where SoLoMo strategies come into play!

What is SoLoMo?? It stands for SOcial, LOcal, and MObile.

Get acquainted with the term as it is increasingly being used and will be commonplace shortly!? SoLoMo refers to how today?s consumers are using social networking, local search, and mobile technology together in their everyday lives, particularly related to product/business research, looking for deals, and making purchases.

Smart Phones are increasingly becoming common and consumers are using Smart Phones on the go to get fast feedback, look for deals, check prices, and make purchases, sometimes while in a store looking at the very product in front of them!? As well, 80% of searches on smartphones are goal-oriented, to find a location or to make a purchase. (adage.com)

Key stats for business owners and marketers related to SoLoMo:

  • By 2014 mobile Internet use is projected to overtake desktop Internet use for good!
  • 50% of all local searches are performed on mobile devices
  • 56% of smartphone users check social media sites on a mobile device daily
  • 88% of smart phone information seekers took action the same day
  • Half of those seeing a mobile Ad take an action on that ad (look for more information or purchase!)

sources: Microsoft 2012, econsultancy.com, business2community

How is your business represented on mobile devices?? Do you have a mobile-friendly website?? Additionally, does your company/store have a presence on Social Media platforms?

TAKEAWAY: This data shows just how important smartphones, social media and location services have become and this will only grow in the next few years.? Businesses must evaluate what technologies and social media services their customers and potential customers are using, and develop a SoLoMo plan to reach out to them in relevant ways on those platforms.

An important consideration is how your website, social, and local strategies all work together.? Try to develop synergies between them.? For example, one SoLoMo idea is for a local retailer to offer a coupon on Facebook targeted to mobile user.

SoLoMo is here to stay!? Is your business ready?

Source: http://www.business2community.com/social-media/solomo-and-your-business-why-you-should-care-0313340

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Tuesday, October 23, 2012

Caterpillar cuts 2012 guidance on weak economy

MINNEAPOLIS (AP) ? Caterpillar says the global economy is weaker than previously thought, and it's cutting its profit and revenue guidance for 2012.

Caterpillar Inc. is the world's largest construction and mining equipment maker, so its results are watched closely as a sign of where the broader economy is headed.

Profit in the third-quarter was almost $1.7 billion, or $2.54 per share. That was up from $1.14 billion, or $1.71per share, a year earlier. Revenue rose 4.6 percent to $16.45 billion.

The results included a $273 million gain from selling a majority interest in a logistics business.

The company now expects 2012 revenue of $66 billion, with profit of $9 to $9.25 per share. Analysts surveyed by FactSet had expected revenue of $67.2 billion, with profit of $9.41 per share.

Source: http://news.yahoo.com/caterpillar-cuts-2012-guidance-weak-economy-121437908--finance.html

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